Ovarian cancer therapy boosts survival
Leigh Dayton, Science writer
January 06, 2006
THE prestigious US National Cancer Institute has backed research showing that a 40-year-old method of treating deadly ovarian cancer increases survival by more than a year.
The NCI’s endorsement of the technique - which delivers cancer-killing drugs directly to the abdomen - came yesterday as the seven-year study of 429 women with advanced ovarian cancer was published in the New England Journal of Medicine.
“The National Cancer Institute wants to make certain the results of clinical research are rapidly disseminated to healthcare providers and patients, to ensure life-enhancing cancer treatments are widely available,” said NCI director Andrew von Eschenbach.
The reason for haste is that ovarian cancer is the most deadly of all women’s cancers, with only 45per cent surviving five years after being diagnosed. This is because there are no symptoms until the cancer has spread and no reliable screening tests.
But a team of US investigators - led by oncologist Deborah Armstrong of the Johns Hopkins Kimmel Centre in Baltimore, Maryland - found women receiving the treatment, called intraperitoneal (IP) chemotherapy, lived an average of 65.6 months after surgery, 25per cent longer than those receiving standard drug therapy.
“There’s been a prejudice against IP therapy in ovarian cancer because it’s an old idea, it requires skill and experience … and it’s more complicated than (standard) chemotherapy,” Associate Professor Armstrong said.
The side-effects of IP therapy, including suppressed blood counts and neurological problems, are initially worse than those for standard chemotherapy.
But Associate Professor Armstrong’s team found that a year after treatment, patients who had received IP chemotherapy were on a par with those receiving conventional chemotherapy.
Specialist Peter Grant, of Melbourne’s Mercy Hospital for Women, welcomed the findings.
“This is very good news,” said Dr Grant, an expert with the National Breast Cancer Centre’s ovarian cancer program.
“Within the clinical setting in Australia this treatment will become a standard treatment offered to many women.”
The advantage of IP therapy is that it bathes the abdomen with a high concentration of potent anti-cancer medication, killing any cancer cells lingering after the tumour has been removed. Conventional chemotherapy works outside the abdomen.
Dr Grant said the new data confirmed the belief of many cancer specialists that a combination of surgery followed by IP and conventional chemotherapy would help most women with advanced ovarian cancer.